FEVERAL 100ML INJECTION ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Paracetamol 1g + Lidocaine HCl (Intravenous Infusion)

MANUFACTURER: Surge Laboratories

QUANTITY

100 ml IV infusion bottle

INDICATION

Feveral 100ml Injection is indicated for the short-term management of moderate to severe pain and fever in adults and children when oral administration is not possible or appropriate. The addition of lidocaine helps reduce infusion site pain and provides supplementary local analgesic effect, making it suitable for post-operative pain, acute febrile illness requiring IV therapy, and perioperative analgesia.

MECHANISM OF ACTION

Paracetamol exerts its analgesic effect by inhibiting prostaglandin synthesis in the central nervous system, primarily through COX-3 inhibition in the brain, and by modulating serotonergic and endocannabinoid pathways. Its antipyretic action results from inhibition of prostaglandin E2 synthesis in the hypothalamic thermoregulatory center, resetting the elevated temperature set point toward normal. IV administration achieves rapid onset of action within 5 to 10 minutes. Lidocaine HCl is a local anesthetic and antiarrhythmic that blocks voltage-gated sodium channels, stabilizing neuronal membranes and reducing infusion-related discomfort. It also contributes complementary analgesic effects through suppression of peripheral and central pain sensitization.

DOSAGE AND ADMINISTRATION

· Adults and adolescents above 50kg: 1g paracetamol (100ml) every 4 to 6 hours intravenously.

· Administered as a 15-minute IV infusion.

· Do not exceed the maximum daily paracetamol dose.

· Reduce dosing frequency in patients with hepatic impairment or renal insufficiency.

· Administer only under medical supervision.

SIDE EFFECTS

Common:

• Mild nausea or headache

• Mild warmth or discomfort at the infusion site

Less common:

• Hypersensitivity reactions including skin rash in rare cases

• Elevation of liver enzymes, particularly with overdose or prolonged use

• Dizziness or lightheadedness due to lidocaine component at higher doses

NOT RECOMMENDED IN

• Severe hepatic impairment or active liver disease

• Known hypersensitivity to paracetamol or lidocaine

• Patients with known hypersensitivity to amide-type local anesthetics

• Patients with severe cardiac conduction disorders due to lidocaine component

DRUG INTERACTIONS

• Chronic alcohol use increases hepatotoxicity risk with paracetamol

• Warfarin anticoagulation may be slightly enhanced with regular paracetamol use

• Antiarrhythmic drugs may have additive cardiac effects with the lidocaine component

• Hepatotoxic drugs such as isoniazid may increase liver damage risk with paracetamol

STORAGE INSTRUCTIONS

Store at room temperature between 15 to 25 degrees Celsius. Protect from light. Do not freeze. Single use only. Do not use if the solution is discolored or contains visible particles.

WHERE TO BUY

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Paracetamol1gm