ACEFYL RESP 125 SYRUP 125ML LARGE ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Acefylline Piperazine 125mg/5ml

MANUFACTURER: Nabi Qasim Industries (Pvt) Ltd

QUANTITY:

125ml syrup

INDICATION

Acefyl Resp 125 Syrup is a xanthine bronchodilator indicated for the relief of bronchospasm in bronchial asthma, chronic bronchitis, and other reversible obstructive airway diseases in adults and children. It is used to reduce wheezing, breathlessness, and chest tightness associated with acute and chronic airway obstruction. The syrup formulation makes it particularly suitable for pediatric patients and adults who have difficulty swallowing solid dosage forms. It is commonly prescribed as an adjunctive bronchodilator alongside inhaled therapies in chronic respiratory disease management.

MECHANISM OF ACTION

Acefylline piperazine is a piperazine salt of theophylline that combines the bronchodilatory properties of theophylline with better gastrointestinal tolerability than plain theophylline. It inhibits phosphodiesterase enzymes in bronchial smooth muscle, increasing intracellular cyclic AMP, which causes smooth muscle relaxation and bronchodilation. The piperazine moiety improves water solubility and reduces gastrointestinal irritation. Acefylline also has mild anti-inflammatory properties, reduces mucociliary dysfunction, and improves diaphragmatic contractility in patients with COPD.

DOSAGE AND ADMINISTRATION

• Adults: 200 to 400mg (8 to 16ml) two to three times daily

• Children 6 to 12 years: 100 to 200mg (4 to 8ml) two to three times daily

• Children 2 to 6 years: 50 to 100mg (2 to 4ml) two to three times daily

• Take with or after meals to reduce gastrointestinal irritation; always follow the dosage prescribed by your doctor

SIDE EFFECTS

Common:

• Nausea and vomiting

• Headache and dizziness

• Palpitations and tachycardia

• Restlessness and insomnia

Less common:

• Seizures at toxic plasma levels

• Cardiac arrhythmias with excessive dosing

• Hypotension

• Gastrointestinal cramps and diarrhoea

NOT RECOMMENDED IN

• Known hypersensitivity to theophylline or xanthine derivatives

• Acute myocardial infarction

• Peptic ulcer disease (xanthine’s can increase gastric acid secretion)

• Caution in epilepsy, hyperthyroidism, and severe hepatic impairment

DRUG INTERACTIONS

Erythromycin, cimetidine, ciprofloxacin, and allopurinol inhibit theophylline metabolism, increasing plasma levels and toxicity risk; monitor closely. Rifampicin, carbamazepine, and phenobarbitone induce xanthine metabolism, reducing efficacy. Caffeine has additive CNS and cardiovascular stimulant effects; advise patients to limit coffee and tea. Beta-blockers may antagonize the bronchodilatory effect. Phenytoin reduces theophylline levels through enzyme induction.

STORAGE INSTRUCTIONS

Store below 25°C in a dry place away from direct sunlight. Keep tightly closed. Keep out of reach of children.

WHERE TO BUY

You can buy Acefyl Resp 125 Syrup 125ml Large online from Dawa Healthcare Pharmacy at dawahealthcare.biz, one of Pakistan's most trusted pharmacies for authentic, pharmacist-verified medicines. Browse our product page to check the current Acefyl Resp 125 Syrup 125ml Large price in pakistan, read detailed clinical information, and place your order from the comfort of your home. Our experienced pharmacy team is always available to answer your questions about Acefyl Resp 125 Syrup 125ml Large uses and correct dosage. Customers in Karachi enjoy same-day delivery on orders placed before the daily cutoff, while customers across Pakistan benefit from our nationwide courier service for safe and timely delivery to any city. You can also visit any of our Karachi branches in person or reach our dedicated WhatsApp support team for instant help Acefyl Resp 125 Syrup 125ml Large uses, pricing, prescriptions, and order placement.